Dr Platt is a leading expert on the subject of how immunity injures grafts. His research has elucidated how pore forming proteins, such a perforin and the membrane attack complex, injure endothelial cells (the cells that line blood vessels). Endothelial cells are the key target of immune reactions against transplants and understanding how immunity injures these cells constitutes a central goal of the field of transplantation.
Dr Platt investigates how grafts, or any tissues, acquire resistance to immune-mediated injury, a phenomenon Dr Platt originally described and named "accommodation”. Accommodation may be vital to the survival and function of organ transplants and to the eradication of infectious organisms without unwanted destruction of tissue.
Dr Platt investigates how diverse repertoires of B cells and T cells develop, and how these repertoires can be reconstituted for treatment of immunodeficiency, chronic viral infection, and cancer. This research includes international collaborations addressing the acquired immunodeficiency syndrome (AIDS) and heart transplantation in young infants.
Dr Platt investigates how endogenous agonists activate toll like receptors in health and disease, interaction of stem cells and engineered tissues with the immune system and the mechanisms and implications of cell fusion.